Infectivity of adeno-associated virus serotypes in mouse testis
نویسندگان
چکیده
منابع مشابه
Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps.
The limited packaging capacity of adeno-associated virus (AAV) precludes the design of vectors for the treatment of diseases associated with larger genes. Autonomous parvoviruses, such as minute virus of mice and B19, while identical in size (25 nm), are known to package larger genomes of 5.1 and 5.6 kb, respectively, compared to AAV genomes of 4.7 kb. One primary difference is the fact that wi...
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Recombinant adeno-associated viral (AAV) vectors have rapidly advanced to the forefront of gene therapy in the past decade. The exponential progress of AAV-based vectors has been made possible by the isolation of several naturally occurring AAV serotypes and over 100 AAV variants from different animal species. These isolates are ideally suited to development into human gene therapy vectors due ...
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ژورنال
عنوان ژورنال: BMC Biotechnology
سال: 2018
ISSN: 1472-6750
DOI: 10.1186/s12896-018-0479-1